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FUNDED GRANTS: 2021

GRANTS AWARDED IN 2021

MASSACHUSETTES GENERAL HOSPITAL

Efficacy of high dose booster vaccination in vaccine non-responsive immunosuppressed individuals

 

Grantee will test whether booster vaccination enhances the protection of immunocompromised individuals to COVID-19. Grantee and others showed that heart and lung transplant recipients, who are heavily immunosuppressed, respond poorly to standard SARS-CoV-2 vaccination regimens. Specifically, Grantee will test whether a third dose that consists of twice the amount of immune stimulus and/or a third dose in standard amounts leads to enhanced antibody and/or cellular immune responses in these individuals. Better protection would enable immunocompromised individuals to safely return to their pre-pandemic lives.

 

Principal Investigator: Marcia Goldberg, MD

Awarded: September 2021

Duration: 12 months

Amount of Award: $150,000

 

 

UNIVERSITY OF ALBERTA

Molecular Characterization of Baseline Lung Allograft Dysfunction

 

Lung transplantation is essential for patients with end-stage lung disease, but in many cases the function of the transplant after recovering from surgery (“baseline”) is below the level required for that patient to experience normal breathing, quality of life and life expectancy. The reasons behind this impaired baseline function, and the pathology underlying it, are not known. Grantee hypothesizes that this dysfunction reflects tissue damage that can be measured molecularly, and that is Grantee can define and measure these changes Grantee can devise methods of preventing and treating this tissue damage.

 

Principal Investigator: Kieran Halloran, MD

Awarded: September 2021

Duration: 24 months

Awarded: $147,695

 

 

UNIVERSITY HEALTH NETWORK

Delineating the Biological Mechanisms of Grant Fibrosis in Liver Transplant Recipients

 

The lifespan of the transplanted liver is finite, with scarring (fibrosis) developing over time in the vast majority. Graft fibrosis accumulates more rapidly than in the native liver and the biological reasons are poorly understood. In this study, Grantee will examine liver samples after transplant, to understand the contribution of graft age, capacity to regenerate, and activity of cells that accelerate scarring. Grantee will use techniques to characterize cell types and signaling pathways that drive fibrosis. These findings will provide insight into therapeutics to prolong graft survival.

 

Principal Investigator: Mamatha Bhat, MD, MSc, PhD, FRCPC

Awarded: September 2021

Duration: 12 months

Awarded: $150,000

 

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